Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs

Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Two akin suitcases of speedily progressive fibrosing interstitial nephritis in childish women who followed the same light regimen prompted us to conduct an epidemiological survey of the nephrology centres of Brussels and to additional investigate the exact nature of this light behavior.

Seven other women under the age of 50 in terminal or preterminal renal failure were admitted pro dialysis in 1991 and 1992. They had all followed a light regimen in the same health check clinic. Renal biopsy samples in eight of the nine suitcases showed extensive interstitial fibrosis lacking glomerular lesions. Two of the patients were seen pro the initially calculate in terminal renal failure and were ongoing at once on dialysis. For the seven other women, the nephropathy was characterised by a rapid wear in renal function, with early serum creatinine doubling surrounded by in this area 3 months. The clinic had specialised in light treatments pro the before 15 years lacking one problems. Inside May, 1990, therapy was altered, with the introduction of two Chinese herbs (Stephania tetrandra and Magnolia officinalis). Inside June, 1992, three of twenty-five at random selected women who had followed the same regimen all through by smallest amount 3 months from 1990 had impaired renal function. Chemical analysis of approximately brands of these Chinese herbs did not trade show nephrotoxic contaminants of fungal or sow origin (ochratoxin or aristolochic acid) or sullying by diuretics or antiinflammatory drugs. However, the medicinal training of the capsules taken by patients had uncommon alkaloid profiles from persons probable in Chinese plants.

The striking relation linking a point type of fibrosing interstitial nephritis in childish women and a light behavior relating Chinese herbs adds support to the arguments hostile to abandoned therapy with herbal preparations.

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